If you're fat then the lipid nanoparticles get lost in the fat, and even if they do somehow make it to the blood vessels, well, with all those plaques in the way how are they going to transfect? Is this vaccine revenge of the fatties against all the fit people with squeaky-clean arteries and 0% body fat?
If you're fat then the lipid nanoparticles get lost in the fat, and even if they do somehow make it to the blood vessels, well, with all those plaques in the way how are they going to transfect? Is this vaccine revenge of the fatties against all the fit people with squeaky-clean arteries and 0% body fat?
LNPs don't "get lost in the fat", they attach to whatever cell membranes they come into contact with. And the presence of arterial plaque will have zero effect on their ability to bond to ACE2 receptors in vascular endothelium. Arterial plaque is only ever present in lesions representing a tiny part of the interior surface of the larger arteries. It does NOT line the arteries like clogged plumbing pipes! So your imagery doesn't work.
If you're fat then the lipid nanoparticles get lost in the fat, and even if they do somehow make it to the blood vessels, well, with all those plaques in the way how are they going to transfect? Is this vaccine revenge of the fatties against all the fit people with squeaky-clean arteries and 0% body fat?
LNPs don't "get lost in the fat", they attach to whatever cell membranes they come into contact with. And the presence of arterial plaque will have zero effect on their ability to bond to ACE2 receptors in vascular endothelium. Arterial plaque is only ever present in lesions representing a tiny part of the interior surface of the larger arteries. It does NOT line the arteries like clogged plumbing pipes! So your imagery doesn't work.
Somehow make it to the blood vessels? There is no way they don't.
Maybe not for a fit or skinny person but a morbidly obese person? I dunno...