In addition, several typical mechanisms underlying GFN toxicity have been revealed, for
instance, physical destruction, oxidative stress, DNA damage, inflammatory response,
apoptosis, autophagy, and necrosis. In these mechanisms, (toll-like receptors-) TLR-,
transforming growth factor β- (TGF-β-) and tumor necrosis factor-alpha (TNF-α) dependent pathways are involved in the signaling pathway network, and oxidative stress plays a
crucial role in these pathways.
Another study suggested that the irregular protrusions and sharp edges of the nanosheets could damage the plasma membrane, thus letting G entering the cell by piercing the phospholipid-bilayer (Li Y. et al., 2013). These features raise additional safety concerns, as free GRMs in the cytoplasm may lead to disruption of the cytoskeleton, impaired cell motility and blockade of the cell-cycle, similar to carbon nanotube-induced cytotoxicity. Exposed larvae displayed GO in the CNS and, most importantly, an induction of Parkinson’s disease-like symptoms such as disturbance of locomotor activity, dopaminergic neurons loss and formation of Lewy bodies. These effects were likely a consequence of mitochondrial damage and apoptosis through the caspase 8 pathway, in the presence of a more general metabolic disturbance
Two recent studies give us a less than rosy angle. In the first, a team of biologists, engineers and material scientists at Brown University examined graphene’s potential toxicity in human cells. They found that the jagged edges of graphene nanoparticles, super sharp and super strong, easily pierced through cell membranes in human lung, skin and immune cells, suggesting the potential to do serious damage in humans and other animals.
Generally, GFNs may exert different degrees of toxicity in animals or cell models by following with different administration routes and penetrating through physiological barriers, subsequently being distributed in tissues or located in cells, eventually being excreted out of the bodies. This review collects studies on the toxic effects of GFNs in several organs and cell models. We also point out that various factors determine the toxicity of GFNs including the lateral size, surface structure, functionalization, charge, impurities, aggregations, and corona effect ect. In addition, several typical mechanisms underlying GFN toxicity have been revealed, for instance, physical destruction, oxidative stress, DNA damage, inflammatory response, apoptosis, autophagy, and necrosis.
If you consider the implications of the DOD developing the Pfizer jab as a prototype countermeasure as described by Sasha Latypova, the DOD can instruct Pfizer to vary the contents of the inoculations as investigation of prototypes. The implication is that some vials will contain graphene and some not. Dr. Ryan Cole in conjunction with a mass spec lab recent analyzed a number of vials and found no graphene in any of them and found no mRNA is some of them as well (essential vials of saline). Others contained degraded mRNA with varying percentages of intact "jab spike protein" mRNA.. My interpretation is the jabs are a combination of different DOD prototypes and poor manufacturing quality control On another note, I appreciate all your links to research on graphene. Graphene is clearly toxic and it reportedly used in the limpid nanoparticles that come from a Chinese manufacturer (they state this on their website) as noted by Karen Kingston. With regard to ROS, toxins and viruses and pathogenic bacteria also elevate ROS. That graphene could be synergistic with pathogens in elevating ROS and misfolding of proteins and creating and inducing amyloid proteins is not beyond a possibility. Dr. Arne Bukhardt's autopsy biopsy slides clearly show amyloid infiltration of critical organs including the heart and brain and well as the spike protein "mRNA infections" triggering killer lymphocyte attacks on infected cells and consequent scarring.
So, the presence of toxic graphene can cause amyloidosis. However, if the technology used in these injections is also based on peptides (as has been widely reported in the scientific literature: Self-assembling peptide semiconductors | https://www.science.org/doi/10.1126/science.aam9756), the production of amyloid in the bone marrow can lead to severe amyloidosis and related complications and death, including the currently manifested so-called sudden death syndrome. The key question, therefore, is also what technology was used in these injections.
“Short peptides, specifically those containing aromatic amino acids, can self-assemble into a wide variety of supramolecular structures that are kinetically or thermodynamically stable; the representative models are diphenylalanine and phenylalanine-tryptophan. Different assembly strategies can be used to generate specific functional organizations and nanostructural arrays, resulting in finely tunable morphologies with controllable semiconducting characteristics. Such strategies include molecular modification, microfluidics, coassembly, physical or chemical vapor deposition, and introduction of an external electromagnetic field (EMF).
Self-assembling peptide nanomaterials may serve as an alternative source for the semiconductor industry because they are eco-friendly, morphologically and functionally flexible, and easy to prepare, modify, and dope. Moreover, the diverse bottom-up methodologies of peptide self-assembly facilitate easy and cost-effective device fabrication, with the ability to integrate external functional moieties. For example, the coassembly of peptides and electron donors or acceptors can be used to construct n-p junctions, and vapor deposition technology can be applied to manufacture custom-designed electronics and chips on various substrates.
The inherent bioinspired nature of self-assembling peptide nanostructures allows them to bridge the gap between the semiconductor world and biological systems, thus making them useful for applications in fundamental biology and health care research. Short peptide self-assemblies may shed light on the roles of protein semiconductivity in physiology and pathology. For example, research into the relationship between the semiconductive properties of misfolded polypeptides characteristic of various neurodegenerative diseases and the resulting symptoms may offer opportunities to investigate the mechanisms controlling such ailments and to develop therapeutic solutions. Finally, self-assembling short peptide semiconductors could be used to develop autonomous biomachines operating within biological systems. This would allow, for example, direct, label-free, real-time monitoring of a variety of metabolic activities, and even interference with biological systems.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457452/ “Peptide based nano-assemblies with their self-organizing ability has shown lot of promise due to their high degree of thermal and chemical stability, for biomaterial fabrication. Developing an effective way to control the organization of these structures is important for fabricating application-oriented materials at the molecular level. The present study reports the impact of electric and magnetic field-mediated perturbation of the self-assembly phenomenon, upon the chemical and structural properties of diphenylalanine assembly. Our studies show that, electric field effectively arrests aggregation and self-assembly formation, while the molecule is allowed to anneal in the presence of applied electric fields of varying magnitudes, both AC and DC. The electric field exposure also modulated the morphology of the self-assembled structures without affecting the overall chemical constitution of the material. Our results on the modulatory effect of the electric field are in good agreement with theoretical studies based on molecular dynamics reported earlier on amyloid forming molecular systems.”
“In last decade, there has been an increased focus on organic and bio-organic nano-assemblies. Peptide nanotubes, their physical properties, and assembly morphologies are extensively studied due to their excellent biocompatibility as well as functional and structural diversity. Many ordered supramolecular structures have been constructed using peptides as the building blocks. The most extensively utilized peptide-based building block is diphenylalanine (Phe-Phe or FF), which is the shortest bio-molecule known to self-assemble into ordered nanostructures. FF incidentally is also the core recognition motif of the β-amyloid polypeptide, a peptide associated with Alzheimer’s disease1. It can self-assemble into a variety of structures like microtubes, nanotubes2, microcrystals, nanofibers3, nanorods4, 5 and nanowires6.”
“The potential of these supramolecular structures have been utilized in diverse fields including nanofabrication, drug delivery vehicles7, bio-sensing8, energy storage devices, and hydrogels for tissue engineering”.
“One of the key challenges in the field of supramolecular chemistry has been controlling the self-assembly of molecules into ordered functional units. Previously, a number of strategies including pH mediated control21, 22, solvent mediated control23, covalent modifications24, vapour deposition25, 26, temperature27, surface28, 29, relative humidity30, symmetry31 and magnetite coating on the surface of nanotubes32 have been employed to regulate the architecture of diphenylalanine self-assemblies.”
Andrij Baumketner in a recent study, explored the feasibility of using external electric field to disaggregate amyloid fibrils, by inducing folding into an α-helical state reducing their β sheet conformation38. This is especially important because FF is the core recognition motif of β-amyloid segment. Here in this study, we attempt to confirm the effect of AC (Alternating Current) and DC (Direct Current) electric field on diphenylalanine self-assembly using experimental approach.
Different assembly strategies can be used to generate specific functional organizations and nano structural arrays, resulting in finely tunable morphologies with controllable semiconducting characteristics. Such strategies include molecular modification, microfluidics, subassembly, physical or chemical vapor deposition, and introduction of an external electromagnetic field.
CAN YOU IMAGINE IT BEING USED IN MASKS, TESTS, INJECTIONS, FOOD, AIR, ETC.?
Dr. Noack was a real expert on the subject.... As far as I remember, he looked at the spectroscopy results provided by Dr. Campra.
If Dr. Campra was right, Dr. Noack knew the exact answer.
https://www.nature.com/articles/srep07419
But even if it wasn't hydroxide, it's still extremely sharp and toxic. These people are guilty of mass murder.
However, Dr. Noack said it is not biodegradable. But there are studies that it is biodegradable.
Physical damage is one mechanism of damage caused by graphene.
"Furthermore, the sharpened edges of GNS may act as ‘blades’, inserting and cutting through bacterial cell membranes"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088662/#CR173
https://pubmed.ncbi.nlm.nih.gov/20925398/
Moreover, the extremely sharp edges of graphene nanowalls were found to damage the membrane of the microorganism by direct contact
https://www.researchgate.net/profile/Xiaolong-Tu/publication/266151786_Assessing_in_vivo_toxicity_of_graphene_materials_Current_methods_and_future_outlook/links/54ed849f0cf28f3e65358d15/Assessing-in-vivo-toxicity-of-graphene-materials-Current-methods-and-future-outlook.pdf
How does graphene damage viruses, bacteria and human cells? Graphene is a thin but
strong and conductive two-dimensional sheet of carbon atoms. There are three ways that it
can help prevent the spread of microbes: – Microscopic graphene particles have sharp
edges that mechanically damage viruses and cells as they pass by them.
http://hdreporter.com/health/9646-are-graphene-coated-face-masks-a-covid-19-miracle-or-another-health-risk
Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms -
PMC Published online 2016 Oct 31. doi: 10.1186/s12989-016-0168-y
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088662/
In addition, several typical mechanisms underlying GFN toxicity have been revealed, for
instance, physical destruction, oxidative stress, DNA damage, inflammatory response,
apoptosis, autophagy, and necrosis. In these mechanisms, (toll-like receptors-) TLR-,
transforming growth factor β- (TGF-β-) and tumor necrosis factor-alpha (TNF-α) dependent pathways are involved in the signaling pathway network, and oxidative stress plays a
crucial role in these pathways.
Another study suggested that the irregular protrusions and sharp edges of the nanosheets could damage the plasma membrane, thus letting G entering the cell by piercing the phospholipid-bilayer (Li Y. et al., 2013). These features raise additional safety concerns, as free GRMs in the cytoplasm may lead to disruption of the cytoskeleton, impaired cell motility and blockade of the cell-cycle, similar to carbon nanotube-induced cytotoxicity. Exposed larvae displayed GO in the CNS and, most importantly, an induction of Parkinson’s disease-like symptoms such as disturbance of locomotor activity, dopaminergic neurons loss and formation of Lewy bodies. These effects were likely a consequence of mitochondrial damage and apoptosis through the caspase 8 pathway, in the presence of a more general metabolic disturbance
https://www.frontiersin.org/articles/10.3389/fnsys.2018.00012/full
Two recent studies give us a less than rosy angle. In the first, a team of biologists, engineers and material scientists at Brown University examined graphene’s potential toxicity in human cells. They found that the jagged edges of graphene nanoparticles, super sharp and super strong, easily pierced through cell membranes in human lung, skin and immune cells, suggesting the potential to do serious damage in humans and other animals.
https://newatlas.com/graphene-bad-for-environment-toxic-for-humans/31851/
Generally, GFNs may exert different degrees of toxicity in animals or cell models by following with different administration routes and penetrating through physiological barriers, subsequently being distributed in tissues or located in cells, eventually being excreted out of the bodies. This review collects studies on the toxic effects of GFNs in several organs and cell models. We also point out that various factors determine the toxicity of GFNs including the lateral size, surface structure, functionalization, charge, impurities, aggregations, and corona effect ect. In addition, several typical mechanisms underlying GFN toxicity have been revealed, for instance, physical destruction, oxidative stress, DNA damage, inflammatory response, apoptosis, autophagy, and necrosis.
https://www.sciencedaily.com/releases/2018/08/180823113613.htm
A human enzyme can biodegrade graphene
https://onlinelibrary.wiley.com/doi/10.1002/anie.201806906
Degradation of Single-Layer and Few-Layer Graphene by Neutrophil Myeloperoxidase
If you consider the implications of the DOD developing the Pfizer jab as a prototype countermeasure as described by Sasha Latypova, the DOD can instruct Pfizer to vary the contents of the inoculations as investigation of prototypes. The implication is that some vials will contain graphene and some not. Dr. Ryan Cole in conjunction with a mass spec lab recent analyzed a number of vials and found no graphene in any of them and found no mRNA is some of them as well (essential vials of saline). Others contained degraded mRNA with varying percentages of intact "jab spike protein" mRNA.. My interpretation is the jabs are a combination of different DOD prototypes and poor manufacturing quality control On another note, I appreciate all your links to research on graphene. Graphene is clearly toxic and it reportedly used in the limpid nanoparticles that come from a Chinese manufacturer (they state this on their website) as noted by Karen Kingston. With regard to ROS, toxins and viruses and pathogenic bacteria also elevate ROS. That graphene could be synergistic with pathogens in elevating ROS and misfolding of proteins and creating and inducing amyloid proteins is not beyond a possibility. Dr. Arne Bukhardt's autopsy biopsy slides clearly show amyloid infiltration of critical organs including the heart and brain and well as the spike protein "mRNA infections" triggering killer lymphocyte attacks on infected cells and consequent scarring.
Absolutely, I see two major factors contributing to injury and death:
amyloid plaque and oxidative stress.
https://outraged.substack.com/p/short-summary
https://outraged.substack.com/p/treatment-in-practice
https://outraged.substack.com/p/causes-of-injuries-and-deaths-from - With more information on amyloids:
The mere presence of toxic graphene, and similar components, can cause amyloidosis.
Amyloidosis is also a common complication after Covid-19 injections, as also confirmed by Pfizer documents listing various types of amyloidosis as possible post-vaccination complications in a Postmarketing Experience document: https://phmpt.org/wp-content/uploads/2021/11/5.3.6-postmarketing-experience.pdf
Amyloid arthropathy;
Amyloidosis;
Amyloidosis senile;
Cardiac amyloidosis;
Cerebral amyloid angiopathy;
Cutaneous amyloidosis;
Dialysis amyloidosis;
Gastrointestinal amyloidosis;
Hepatic amyloidosis;
Primary amyloidosis;
Pulmonary amyloidosis;
Renal amyloidosis;
Secondary amyloidosis;
Tongue amyloidosis; (“Covid tongue”)
So, the presence of toxic graphene can cause amyloidosis. However, if the technology used in these injections is also based on peptides (as has been widely reported in the scientific literature: Self-assembling peptide semiconductors | https://www.science.org/doi/10.1126/science.aam9756), the production of amyloid in the bone marrow can lead to severe amyloidosis and related complications and death, including the currently manifested so-called sudden death syndrome. The key question, therefore, is also what technology was used in these injections.
“Short peptides, specifically those containing aromatic amino acids, can self-assemble into a wide variety of supramolecular structures that are kinetically or thermodynamically stable; the representative models are diphenylalanine and phenylalanine-tryptophan. Different assembly strategies can be used to generate specific functional organizations and nanostructural arrays, resulting in finely tunable morphologies with controllable semiconducting characteristics. Such strategies include molecular modification, microfluidics, coassembly, physical or chemical vapor deposition, and introduction of an external electromagnetic field (EMF).
Self-assembling peptide nanomaterials may serve as an alternative source for the semiconductor industry because they are eco-friendly, morphologically and functionally flexible, and easy to prepare, modify, and dope. Moreover, the diverse bottom-up methodologies of peptide self-assembly facilitate easy and cost-effective device fabrication, with the ability to integrate external functional moieties. For example, the coassembly of peptides and electron donors or acceptors can be used to construct n-p junctions, and vapor deposition technology can be applied to manufacture custom-designed electronics and chips on various substrates.
The inherent bioinspired nature of self-assembling peptide nanostructures allows them to bridge the gap between the semiconductor world and biological systems, thus making them useful for applications in fundamental biology and health care research. Short peptide self-assemblies may shed light on the roles of protein semiconductivity in physiology and pathology. For example, research into the relationship between the semiconductive properties of misfolded polypeptides characteristic of various neurodegenerative diseases and the resulting symptoms may offer opportunities to investigate the mechanisms controlling such ailments and to develop therapeutic solutions. Finally, self-assembling short peptide semiconductors could be used to develop autonomous biomachines operating within biological systems. This would allow, for example, direct, label-free, real-time monitoring of a variety of metabolic activities, and even interference with biological systems.
Amyloid self-assembling peptides: Potential applications in nanovaccine engineering and biosensing https://onlinelibrary.wiley.com/doi/10.1002/pep2.24095
Peptide Semiconductor Times Are Coming | Nature Portfolio Bioengineering Community https://bioengineeringcommunity.nature.com/posts/37570-peptide-semiconductor-times-are-coming
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457452/ “Peptide based nano-assemblies with their self-organizing ability has shown lot of promise due to their high degree of thermal and chemical stability, for biomaterial fabrication. Developing an effective way to control the organization of these structures is important for fabricating application-oriented materials at the molecular level. The present study reports the impact of electric and magnetic field-mediated perturbation of the self-assembly phenomenon, upon the chemical and structural properties of diphenylalanine assembly. Our studies show that, electric field effectively arrests aggregation and self-assembly formation, while the molecule is allowed to anneal in the presence of applied electric fields of varying magnitudes, both AC and DC. The electric field exposure also modulated the morphology of the self-assembled structures without affecting the overall chemical constitution of the material. Our results on the modulatory effect of the electric field are in good agreement with theoretical studies based on molecular dynamics reported earlier on amyloid forming molecular systems.”
“In last decade, there has been an increased focus on organic and bio-organic nano-assemblies. Peptide nanotubes, their physical properties, and assembly morphologies are extensively studied due to their excellent biocompatibility as well as functional and structural diversity. Many ordered supramolecular structures have been constructed using peptides as the building blocks. The most extensively utilized peptide-based building block is diphenylalanine (Phe-Phe or FF), which is the shortest bio-molecule known to self-assemble into ordered nanostructures. FF incidentally is also the core recognition motif of the β-amyloid polypeptide, a peptide associated with Alzheimer’s disease1. It can self-assemble into a variety of structures like microtubes, nanotubes2, microcrystals, nanofibers3, nanorods4, 5 and nanowires6.”
“The potential of these supramolecular structures have been utilized in diverse fields including nanofabrication, drug delivery vehicles7, bio-sensing8, energy storage devices, and hydrogels for tissue engineering”.
“One of the key challenges in the field of supramolecular chemistry has been controlling the self-assembly of molecules into ordered functional units. Previously, a number of strategies including pH mediated control21, 22, solvent mediated control23, covalent modifications24, vapour deposition25, 26, temperature27, surface28, 29, relative humidity30, symmetry31 and magnetite coating on the surface of nanotubes32 have been employed to regulate the architecture of diphenylalanine self-assemblies.”
Andrij Baumketner in a recent study, explored the feasibility of using external electric field to disaggregate amyloid fibrils, by inducing folding into an α-helical state reducing their β sheet conformation38. This is especially important because FF is the core recognition motif of β-amyloid segment. Here in this study, we attempt to confirm the effect of AC (Alternating Current) and DC (Direct Current) electric field on diphenylalanine self-assembly using experimental approach.
Different assembly strategies can be used to generate specific functional organizations and nano structural arrays, resulting in finely tunable morphologies with controllable semiconducting characteristics. Such strategies include molecular modification, microfluidics, subassembly, physical or chemical vapor deposition, and introduction of an external electromagnetic field.
When it comes to Dr. Cole, I trust Dr. Mihalcea:
https://anamihalceamdphd.substack.com/p/you-cant-find-what-you-are-not-looking?utm_source=post-email-title&publication_id=956088&post_id=90239968&isFreemail=true&utm_medium=email