Yeah, that was puzzling to me. The plots (which are posted with very little context) appeared to show that boosting produced reaction to Omicron that was not previously present. One thing I wondered was whether they took a sample just prior to boosting, or they were relying on a long previous sample as the prior. Because one possible exp…
Yeah, that was puzzling to me. The plots (which are posted with very little context) appeared to show that boosting produced reaction to Omicron that was not previously present. One thing I wondered was whether they took a sample just prior to boosting, or they were relying on a long previous sample as the prior. Because one possible explanation for that data is that the subjects had been exposed to Omicron without knowing it, and developed additional AB coverage. It's just hard to figure out why the ABs produced would be substantially different on the third injection. Higher titers makes sense, but a different population?
Yeah, that was puzzling to me. The plots (which are posted with very little context) appeared to show that boosting produced reaction to Omicron that was not previously present. One thing I wondered was whether they took a sample just prior to boosting, or they were relying on a long previous sample as the prior. Because one possible explanation for that data is that the subjects had been exposed to Omicron without knowing it, and developed additional AB coverage. It's just hard to figure out why the ABs produced would be substantially different on the third injection. Higher titers makes sense, but a different population?
Honestly I don’t know what data we can trust anymore.