You can game any study you want to game. In the design, the protocols (with ivermectin they gave too small dose, on an empty stomach to reduce absorption, and started it too late to be effective), or via statistical games (bad assumptions for Bayesian analyses, by counting all who died of COVID as unvaccinated if they were dx’d with it l…
You can game any study you want to game. In the design, the protocols (with ivermectin they gave too small dose, on an empty stomach to reduce absorption, and started it too late to be effective), or via statistical games (bad assumptions for Bayesian analyses, by counting all who died of COVID as unvaccinated if they were dx’d with it less than 2 weeks after their second dose, etc etc etc)
One REALLY has to know their stuff, medically and statistically, to be able to adequately know if a study was gamed.
But since in this case, they are not recommending an existing and cheaper drug (off patent), without doing a thorough review, I will go out on a limb and believe metformin actually is somewhat effective.
All that said, most people do not need to medicate for a very low risk virus at this point. I will take ivermectin or hydroxychloroquine over anything else based on total knowledge to date and recommend them to family and friends in the higher risk age groups.
We do need a well run trial, with the top existing meds all included, to see which one is best for this year’s strain for: reducing days sick, days contagious, reducing hospitalization and death.
You can game any study you want to game. In the design, the protocols (with ivermectin they gave too small dose, on an empty stomach to reduce absorption, and started it too late to be effective), or via statistical games (bad assumptions for Bayesian analyses, by counting all who died of COVID as unvaccinated if they were dx’d with it less than 2 weeks after their second dose, etc etc etc)
One REALLY has to know their stuff, medically and statistically, to be able to adequately know if a study was gamed.
But since in this case, they are not recommending an existing and cheaper drug (off patent), without doing a thorough review, I will go out on a limb and believe metformin actually is somewhat effective.
All that said, most people do not need to medicate for a very low risk virus at this point. I will take ivermectin or hydroxychloroquine over anything else based on total knowledge to date and recommend them to family and friends in the higher risk age groups.
We do need a well run trial, with the top existing meds all included, to see which one is best for this year’s strain for: reducing days sick, days contagious, reducing hospitalization and death.
Hawkeye, that was a spot on intelligent insightful reply. I agree with you on all points. You just said it better than I could.
Thank you.
Thank you!