The MRNA used in the subpar vaccines is synthetic not natural. It doesn’t invoke memory T cells & if it did you wouldn’t require repeated doses especially over months.
The MRNA used in the subpar vaccines is synthetic not natural. It doesn’t invoke memory T cells & if it did you wouldn’t require repeated doses especially over months.
Pseudouridine in mRNA vaccines is an abundant modified nucleoside in non-coding RNAs across many species. Natural immunity wanes within months and does not prevent reinfection from Omicron subvariants.
We next developed an expanded antigen probe panel to better quantify memory B cell specificities to different regions of the spike protein and test how RBD binding by memory B cells may be affected by the mutations found in emerging VOCs. Specifically, we designed B cell tetramers for eight SARS-CoV-2 antigens, including full-length spike, N-terminal domain (NTD), multiple variant RBDs (WT, B.1.1.7, B.1.351, and B.1.617.2), and the S2 domain (Fig. 3, A and B). Spike-specific memory B cells were defined on the basis of a multiple-discrimination approach, with binding to full-length spike plus one or more additional probes. This strategy also allowed us to identify memory B cells that cross-bind all variant RBDs (all variant+). SARS-CoV-2 nucleocapsid was used as a vaccine-irrelevant antigen (but one for which SARS-CoV-2–infected subjects had detectable preexisting immunity; fig. S4, A and B). Full gating strategies are provided in fig. S1B. We also leveraged a separate cohort of health care workers (HCWs) (table S1) who had mild COVID-19 and were sampled longitudinally after a positive serology test to compare vaccine-induced responses with infection alone (40)."
"Memory CD4+ and CD8+ T cell responses to SARS-CoV-2 mRNA vaccines:
In addition to antibodies and memory B cells, memory T cells can contribute to protection upon reexposure to virus. Memory T cell responses have also been shown to be less affected by VOCs than humoral immune responses (21, 50). To determine whether mRNA vaccination induced durable antigen-specific memory T cell responses, we performed a flow cytometric analysis using an activation-induced marker (AIM) assay. PBMCs were stimulated with peptide megapools containing optimized spike epitopes (51, 52). Antigen-specific responses were quantified as the frequency of AIM+ non-naïve T cells in stimulated samples with background subtraction from paired unstimulated controls (Fig. 5, A and B) (19). Full gating strategies are provided in fig. S6. Antigen-specific CD4+ T cells were defined on the basis of coexpression of CD40L and CD200. Antigen-specific CD8+ T cells were defined on the basis of expression of four of five total activation markers, as described previously (19)."
The MRNA used in the subpar vaccines is synthetic not natural. It doesn’t invoke memory T cells & if it did you wouldn’t require repeated doses especially over months.
Pseudouridine in mRNA vaccines is an abundant modified nucleoside in non-coding RNAs across many species. Natural immunity wanes within months and does not prevent reinfection from Omicron subvariants.
https://www.science.org/doi/10.1126/science.abm0829
"Memory B cell responses to major VOCs:
We next developed an expanded antigen probe panel to better quantify memory B cell specificities to different regions of the spike protein and test how RBD binding by memory B cells may be affected by the mutations found in emerging VOCs. Specifically, we designed B cell tetramers for eight SARS-CoV-2 antigens, including full-length spike, N-terminal domain (NTD), multiple variant RBDs (WT, B.1.1.7, B.1.351, and B.1.617.2), and the S2 domain (Fig. 3, A and B). Spike-specific memory B cells were defined on the basis of a multiple-discrimination approach, with binding to full-length spike plus one or more additional probes. This strategy also allowed us to identify memory B cells that cross-bind all variant RBDs (all variant+). SARS-CoV-2 nucleocapsid was used as a vaccine-irrelevant antigen (but one for which SARS-CoV-2–infected subjects had detectable preexisting immunity; fig. S4, A and B). Full gating strategies are provided in fig. S1B. We also leveraged a separate cohort of health care workers (HCWs) (table S1) who had mild COVID-19 and were sampled longitudinally after a positive serology test to compare vaccine-induced responses with infection alone (40)."
"Memory CD4+ and CD8+ T cell responses to SARS-CoV-2 mRNA vaccines:
In addition to antibodies and memory B cells, memory T cells can contribute to protection upon reexposure to virus. Memory T cell responses have also been shown to be less affected by VOCs than humoral immune responses (21, 50). To determine whether mRNA vaccination induced durable antigen-specific memory T cell responses, we performed a flow cytometric analysis using an activation-induced marker (AIM) assay. PBMCs were stimulated with peptide megapools containing optimized spike epitopes (51, 52). Antigen-specific responses were quantified as the frequency of AIM+ non-naïve T cells in stimulated samples with background subtraction from paired unstimulated controls (Fig. 5, A and B) (19). Full gating strategies are provided in fig. S6. Antigen-specific CD4+ T cells were defined on the basis of coexpression of CD40L and CD200. Antigen-specific CD8+ T cells were defined on the basis of expression of four of five total activation markers, as described previously (19)."
Pfizer documents expose they knew these mrna vaccine wanes and becomes zero.
Where is the evidence for mRNA vaccine efficacy becoming zero? https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00122-6/fulltext
Wanes with time? Nah the "vaccines" were shit.