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According to a very interesting article by a retired physician with wide experience, initial batches of many drugs are problematic. He wrote: "the number of patients placed on the new pharmaceutical is usually many times the number of research participants. As a result, bad reactions, including deaths, from the new product that were not seen during the research can emerge." Caveat emptor.

brownstone.org/articles/a-retired-physicians-view-of-american-healthcare/

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