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From Blanco et al. doi.org/10.1016/j.heliy… "The most commonly prescribed antihistamine was cetirizine (46.6%), due its safety profile." "The second and third antihistamines most commonly prescribed were dexchlorpheniramine (35.7%) and ebastine (1.7%)."
For mode of action, I refer you to Malone et al. doi.org/10.3389/fphar.2… - we propose…
From Blanco et al. https://doi.org/10.1016/j.heliyon.2023.e15772 "The most commonly prescribed antihistamine was cetirizine (46.6%), due its safety profile." "The second and third antihistamines most commonly prescribed were dexchlorpheniramine (35.7%) and ebastine (1.7%)."
For mode of action, I refer you to Malone et al. https://doi.org/10.3389/fphar.2021.633680 - we proposed that dysregulation of mast cells is important in COVID-19.
Aspirin is also a mast-cell stabilizer plus a cox-1 (stronger) and cox-2 inhibitor - see also: https://dx.doi.org/10.2139/ssrn.3646583 for blocking cox-2 with celecoxib combined with high dose famotidine. Clinical evidence supporting aspirin include: https://doi.org/10.1371/journal.pone.0246825, https://doi.org/10.1097/ALN.0000000000003999, and 10.1213/ANE.0000000000005292